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CAS No. : 864814-88-0

MCE 國(guó)際站：Resminostat

產(chǎn)品活性：Resminostat (RAS2410; 4SC-201) 是一種有效的 HDAC1，HHDAC3 和 HDAC6 抑制劑，IC₅₀ 值分別為 42.5，50.1，71.8 nM，同時(shí)對(duì) HDAC8 有較弱的抑制作用，IC₅₀ 值為 877 nM。

研究領(lǐng)域：Cell Cycle/DNA Damage  |  Epigenetics

作用靶點(diǎn)：HDAC

In Vitro: Resminostat (RAS2410; 4SC-201; 5 μM) induces histone acetylation in myeloma cells. Resminostat hydrochloride displays a substrate competitive binding mode with a mean K_i value of 27 nM. Resminostat hydrochloride (5 μM) induces histone hyperacetylation in myeloma cells. Resminostat inhibits cell growth, induces apoptosis and inhibits MM cell proliferation. Resminostat (5 μM) also modulates expression of bcl-2 family proteins and inhibits Akt pathway signalling downstream of Akt. Resminostat exerts synergistic activity against myeloma cells when combined with common and new anti-myeloma agents.
Resminostat inhibits cell growth in head and neck squamous cell carcinoma cell lines, with IC₅₀s ranging from 0.775 μM to 1.572 μM (IC₅₀ for SCC25: 0.775 μM; CAL27: 1.572 μM; and FaDu: 0.899 μM). Resminostat (1.25 and 2.5 μM) has a synergistic effect with irradiation on HNSCC cell lines. Resminostat in combination with cisplatin induces a downregulation of survivin. However, Resminostat shows no effect on Mcl-1 and p-AKT expression.
Resminostat reduces viability of HCC cells with the co-treatment of AZD-2014, with IC₅₀s ranging from 0.89 ± 0.12 μM to 0.07 ± 0.01 μM.

相關(guān)產(chǎn)品：Trichostatin A  |  4-Phenylbutyric acid  |  Valproic acid  |  Entinostat  |  Sulforaphane  |  Romidepsin  |  RGFP966  |  Tasquinimod  |  Corin  |  Tacedinaline  |  Dacinostat  |  ITSA-1  |  SIS17  |  Tubastatin A Hydrochloride  |  WT-161  |  Givinostat hydrochloride monohydrate  |  Pyroxamide  |  Scriptaid  |  BRD-6929  |  Bufexamac  |  HDAC8-IN-1  |  Sinapinic acid  |  Apicidin  |  BML-210  |  HDACs/mTOR Inhibitor 1  |  M344  |  Droxinostat  |  CG347B

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