MCE 的所有產品僅用作科學研究，我們不為任何個人用途提供產品和服務。

Methyllycaconitine citrate

CAS No. : 351344-10-0

MCE 國際站：Methyllycaconitine citrate

產品活性：Methyllycaconitine citrate 是 α7 神經元煙堿型乙酰膽堿受體 (α7nAChR) 的特異性拮抗劑。

研究領域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶點：nAChR

In Vitro: Pretreatment with 5 and 10 μM Methyllycaconitine citrate (MLA) inhibits the decreased cell viability induced by Aβ_25-35. Cell viability does not decrease after exposure to Methyllycaconitine citrate (2.5, 5, 10, 20 μM). Aβ_25-35 treatment increases LC3-II levels, which is inhibited by administration of Methyllycaconitine citrate. Methyllycaconitine citrate also inhibits Aβ-induced autophagosome accumulation in SH-SY5Y cells. Flow cytometry also demonstrates decreased MDC-labeled vacuoles with Methyllycaconitine citrate treatment.

In Vivo: Methyllycaconitine citrate (MLA) (6 mg/kg) given alone intraperitoneally does not cause climbing behavior when compare with the saline group. Pretreatment with Methyllycaconitine citrate significantly inhibits methamphetamine (METH)-induced climbing behavior, by about 50%. Methyllycaconitine citrate does not modify either basal locomotor activity or METH-induced hyperlocomotion. The METH-induced depletion of dopamine neuron terminals is attenuated in mice pretreated with Methyllycaconitine citrate (250±43 fmol/mg, n=7). A direct effect of Methyllycaconitine citrate on body temperature is ruled out because Methyllycaconitine citrate does not affect basal body temperature (37.0±0.5°C, n=5) or reduce the METH-induced hyperthermia (38.2±0.4°C, n=6, MLA+METH group, n.s. versus METH group).

相關產品：Anti-Infection Compound Library  |  Neuronal Signaling Compound Library  |  Bioactive Compound Library Plus  |  Membrane Transporter/Ion Channel Compound Library  |  Carbamoylcholine chloride  |  PNU-282987  |  GTS-21 dihydrochloride  |  Benzethonium chloride  |  Encenicline hydrochloride  |  Pancuronium dibromide  |  Sofiniclin  |  Anabasine  |  Desformylflustrabromine hydrochloride  |  Dinotefuran  |  Meclofenoxate hydrochloride  |  Monepantel  |  PNU-120596  |  Tebanicline hydrochloride  |  Varenicline  |  Adiphenine hydrochloride  |  Hexamethonium Bromide  |  Lobeline hydrochloride  |  (+)-Sparteine  |  ZSET1446  |  Aniracetam  |  Atracurium besylate  |  Cholesterol myristate  |  Decamethonium Bromide  |  Vecuronium bromide  |  A-867744  |  CCMI  |  Cisatracurium besylate

品牌介紹:
•   MCE (MedChemExpress) 擁有數百種全球獨家化合物，我們致力于為全球科研客戶提供最新最全的高品質小分子活性化合物；
•   10,000 多種高選擇性抑制劑、激動劑涉及各熱門信號通路及疾病領域；
•   設有專業的實驗中心和嚴格的質控、驗證體系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各項質檢報告，確保產品的高純度、高品質；
•   產品的生物活性多經各國客戶實驗驗證；
•   Nature, Cell, Science 等多種頂級期刊及制藥專利收錄了MCE客戶的科研成果；
•   專業團隊跟蹤最新的制藥及生命科學研究進展，為您提供全球最新的活性化合物；
•   與世界各大制藥公司及知名科研機構建立了長期的合作。