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CAS No. : 195615-84-0

MCE 國際站：Blarcamesine hydrochloride

產品活性：Blarcamesine hydrochloride 是一個 Sigma-1 受體激動劑，其 IC₅₀ 值為 860 nM。

研究領域：GPCR/G Protein  |  Neuronal Signaling

作用靶點：Sigma Receptor

In Vivo: The pre-administration of Blarcamesine leads to a dose-dependent attenuation of the scopolamine induced alternation deficit, significant at 1 and 3 mg/kg. The pre-treatment with Blarcamesine hydrochloride attenuates the impairments of step-through latency, dose dependently and significantly at doses higher than 0.3 mg/kg. The Blarcamesine hydrochloride treatment dose-dependently blocks the recognition memory deficit, with a significant effect measured at 1 mg/kg. One day after injections, the significant Aβ_25-35-induced decrease in Akt phosphorylation is significantly attenuated by Blarcamesine hydrochloride at 0.1 and 1 mg/kg dose. Seven days after injections, Blarcamesine hydrochloride attenuates the decrease in Ser⁹ phosphorylation induced by the peptide at 0.3 and 1 mg/kg. The Blarcamesine hydrochloride treatment dose-dependently prevents the Aβ_25-35-induced increase in Aβ_1-42 content, with a significant effect at the highest dose tested.

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