斯達特(Starter)，國產抗體專家，
產品別名: E-Cadherin Recombinant Rabbit mAb,PBS Only (SDT-438-45)

E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by sequestering β-catenin from its binding to LEF (Lymphoid enhancer factor)/TCF (T cell factor) which serves the function of transcribing genes of the proliferative Wnt signaling pathway. Despite the ongoing debate on whether the loss of E-cadherin is the cause or effect of epithelial-mesenchymal transition (EMT), E-cadherin functional loss has frequently been associated with poor prognosis and survival in patients of various cancers. The dysregulation of E-cadherin expression that leads to carcinogenesis happens mostly at the epigenetic level but there are cases of genetic alterations as well. E-cadherin expression has been linked to the cellular functions of invasiveness reduction, growth inhibition, apoptosis, cell cycle arrest and differentiation.

杭州斯達特專注于抗體研發和制造，其核心團隊深耕抗體研發十五年，提供優質的抗體、蛋白、試劑盒和定制服務，包括科研抗體、CDx和IVD抗原和抗體原料、一步法ELISA試劑盒、鼠兔通用二抗試劑盒以及其他用途的免疫試劑整體解決方案。公司建立了多物種單B細胞抗體開發平臺（兔單抗，鼠類單抗等）、傳統鼠單抗、重組蛋白表達平臺及完善的抗體應用驗證和檢測體系（包括免疫層析，酶聯免疫，流式分析，免疫組化，免疫印跡，免疫熒光，免疫沉淀等）。已正式通過歐盟98/79/EC認證、ISO9001認證和ISO13485認證。 官網點擊查詢：www.starter-bio.com