斯達(dá)特(Starter)，國(guó)產(chǎn)抗體專家，
產(chǎn)品別名: CLEC7A Recombinant Rabbit mAb (S-1043-136)
CLEC7A, also known as Dectin-1, is a type of C-type lectin receptor that is predominantly expressed on immune cells such as macrophages, dendritic cells, and neutrophils. Its primary function is to recognize pathogen-associated molecular patterns (PAMPs), such as fungal β-glucans, triggering immune responses. Upon binding to PAMPs, CLEC7A activates downstream signaling pathways that lead to the production of inflammatory cytokines and the activation of immune cells, which work together to clear pathogens and protect the body from infection. In addition to its role in pathogen recognition and clearance, CLEC7A is also involved in cell adhesion and migration, which are important for cell interactions, signal transduction, and tissue organization. Moreover, recent research has highlighted the role of CLEC7A in neurological conditions. A study published in Advanced Science suggests that CLEC7A plays a critical role in ischemic stroke by exacerbating microglia-mediated synapse elimination, indicating that it may be a potential therapeutic target for stroke treatment. Furthermore, research has shown that CLEC7A, along with TREM2, another immune receptor on microglia, can activate spleen tyrosine kinase (SYK), which is crucial for the activation of microglia into disease-associated microglia (DAM) that clear amyloid-beta (Aβ) plaques in Alzheimer's disease (AD).
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