斯達(dá)特(Starter)，國(guó)產(chǎn)抗體專家，
產(chǎn)品別名: Cleaved PARP1 Recombinant Rabbit mAb (SDT-R084)

PARP1 possesses a nuclear localization sequence (NLS) near the DNA-binding domain and a caspase-cleavage site between the DNA-binding domain and the automodification domain [PMID: 10455009]. During caspasedependent apoptosis, PARP1 is cleaved by caspases 3 and 7 at its caspase-cleavage site into 24-kDa and 89-kDa fragments [PMID: 10497198, PMID: 8358726]. The 24-kDa PARP1 fragment contains the DNAbinding motif and the NLS, whereas the 89-kDa PARP1 fragment contains the automodification and catalytic domains. After PARP1 cleavage by caspase, the 24-kDa PARP1 fragment irreversibly binds to DNA breaks and acts as a transdominant inhibitor of active PARP1, whereas the 89-kDa PARP1 fragment is translocated to the cytoplasm [PMID: 11570811, PMID: 9721847]. Thereby, PARP1 fragmentation by caspase leads to its inactivation, which inhibits DNA repair and facilitates caspase-mediated DNA fragmentation in apoptosis.

杭州斯達(dá)特專注于抗體研發(fā)和制造，其核心團(tuán)隊(duì)深耕抗體研發(fā)十五年，提供優(yōu)質(zhì)的抗體、蛋白、試劑盒和定制服務(wù)，包括科研抗體、CDx和IVD抗原和抗體原料、一步法ELISA試劑盒、鼠兔通用二抗試劑盒以及其他用途的免疫試劑整體解決方案。公司建立了多物種單B細(xì)胞抗體開(kāi)發(fā)平臺(tái)（兔單抗，鼠類單抗等）、傳統(tǒng)鼠單抗、重組蛋白表達(dá)平臺(tái)及完善的抗體應(yīng)用驗(yàn)證和檢測(cè)體系（包括免疫層析，酶聯(lián)免疫，流式分析，免疫組化，免疫印跡，免疫熒光，免疫沉淀等）。已正式通過(guò)歐盟98/79/EC認(rèn)證、ISO9001認(rèn)證和ISO13485認(rèn)證。 官網(wǎng)點(diǎn)擊查詢：www.starter-bio.com