斯達特(Starter)，國產抗體專家，
產品別名: CD25/IL-2Rα Recombinant Rabbit mAb (S-R223)
CD25 is expressed broadly among?leukocytes. The highest surface expression of this protein is on?regulatory T cells (Tregs), where CD25 is expressed constitutively, especially on a subset classified as naturally occurring Tregs. It can also be found on activated?B cells,?NK (natural killer) cells,?thymocytes, and some?myeloid?lineage cells (e.g.?macrophages,?dendritic cells). L2RA?has been used as a marker to identify CD4+FoxP3+?regulatory T cells?in mice, and it has been found that a large proportion of resting?memory T cells?constitutively express IL2RA in humans. Levels of CD25 soluble form, called?sIL-2Rα, has been connected to pathogenesis of?autoimmune diseases?and?cancer. Since sCD25 is produced during immune activation, it is used as one of?biomarkers?to track disease progression and to indicate outcome for clinical disorders. Especially, it is a hallmark for hyper-activated immune system and?cytokine storm, which may lead to multiple organ system failure.
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