斯達(dá)特(Starter)，國產(chǎn)抗體專家，
產(chǎn)品別名: CD112R Recombinant Rabbit mAb (S-1923-22)

CD112R, also known as PVRIG, is a co-inhibitory receptor belonging to the poliovirus receptor (PVR) family. It is a 36kD single-pass transmembrane protein composed of one transmembrane domain, a long intracellular domain, and a single extracellular immunoglobulin variable-like (IgV) domain. CD112R is predominantly expressed on natural killer (NK) cells and T cells, especially CD8+ T cells, and its expression is upregulated upon activation. In the tumor microenvironment, CD112R is highly expressed on NK cells, CD4+ T cells, and CD8+ T cells. It binds to its ligand CD112 (NECTIN2 or PVRL2) with high affinity, inhibiting the activation of T cells and NK cells, thus contributing to immune evasion in cancer. This makes the CD112R/CD112 axis a potential target for cancer immunotherapy.

杭州斯達(dá)特專注于抗體研發(fā)和制造，其核心團(tuán)隊深耕抗體研發(fā)十五年，提供優(yōu)質(zhì)的抗體、蛋白、試劑盒和定制服務(wù)，包括科研抗體、CDx和IVD抗原和抗體原料、一步法ELISA試劑盒、鼠兔通用二抗試劑盒以及其他用途的免疫試劑整體解決方案。公司建立了多物種單B細(xì)胞抗體開發(fā)平臺（兔單抗，鼠類單抗等）、傳統(tǒng)鼠單抗、重組蛋白表達(dá)平臺及完善的抗體應(yīng)用驗證和檢測體系（包括免疫層析，酶聯(lián)免疫，流式分析，免疫組化，免疫印跡，免疫熒光，免疫沉淀等）。已正式通過歐盟98/79/EC認(rèn)證、ISO9001認(rèn)證和ISO13485認(rèn)證。 官網(wǎng)點擊查詢：www.starter-bio.com