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103 次 病理靶點MLH1和NaPi2b/SLC34A2的主要功能和在癌癥診斷中的作用 2025-5-9
MLH1靶點簡介MLH1（MutL Homolog 1）蛋白是一種在人類細胞中發(fā)現(xiàn)的DNA修復酶，屬于MutL蛋白家族。MLH1蛋白在DNA錯配修復（Mismatch Repair, MMR）過程中起著關(guān)鍵作用，這一過程可以識別并修復DN
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174 次 運動減輕血流再循環(huán)激活代謝轉(zhuǎn)能器 SCD1 催化血管保護性代謝物 2025-5-7
Exercise mitigates flow recirculation and activates metabolic transducer SCD1 to catalyze vascular protective metabolitesKS：Exercise；flow recirculation；SCD1作為對周期性心臟收縮的
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188 次 靶向軟骨下骨骨細胞中的H19用于減輕骨關(guān)節(jié)炎軟骨降解 2025-5-6
Targeting Long Noncoding RNA H19 in Subchondral Bone Osteocytes and the Alleviation of Cartilage Degradation in OsteoarthritisKWS：LncRNA H19；Subchondral Bone Osteocytes；Cartilag
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234 次 內(nèi)皮雌激素-心肌cGMP軸決定壓力超負荷期間的血管生成和心臟功能 2025-4-28
Endothelial oestrogen-myocardial cyclic guanosine monophosphate axis critically determines angiogenesis and cardiac performance during pressure overloadKeywords: Angiogenesis; Cycl
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259 次 鐵調(diào)素Hepcidin-25作為鐵代謝和免疫反應關(guān)鍵調(diào)節(jié)因子的功能和作用 2025-4-28
在生命科學的探索中，Hepcidin-25（鐵調(diào)素，M28234，AbMole）作為鐵代謝和免疫反應的關(guān)鍵調(diào)節(jié)因子，一直是研究的熱點。它不僅在基礎(chǔ)生物學中扮演著重要角色，還為理解生物體內(nèi)的復雜機制提供了新
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269 次 揭秘TH17細胞分化“開關(guān)”：ChIP-seq 技術(shù)破解基因調(diào)控密碼 2025-4-27
2017年發(fā)表在Nature上的“Reversing SKI–SMAD4-mediated suppression is essential for TH17 cell differentiation”的文章揭示了TGFβ的“反向調(diào)控”策略：正常
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273 次 機械拉伸誘導的活性氧驅(qū)動新生豬腎上皮細胞內(nèi)皮素的產(chǎn)生 2025-4-27
Induction of reactive oxygen species by mechanical stretch drives endothelin production in neonatal pig renal epithelial cellsKeywords: Acute kidney injury; Endothelin; Endothelin
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287 次 Hes1/Piezo1 通路在糖皮質(zhì)激素誘導的骨質(zhì)疏松癥中的關(guān)鍵作用 2025-4-22
The pivotal role of the Hes1/Piezo1 pathway in the pathophysiology of glucocorticoid-induced osteoporosisKeywords: Bone biology; Bone disease; Osteoporosis; Therapeutics.糖皮質(zhì)激素
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294 次 大腦通過 PGE2 骨內(nèi)感受調(diào)節(jié)負重骨：踝關(guān)節(jié)骨性關(guān)節(jié)炎和疼痛的影響 2025-4-21
Brain regulates weight bearing bone through PGE2 skeletal interoception: implication of ankle osteoarthritis and painSubject terms: Bone, Pathogenesis內(nèi)感受（Interoception）是一種監(jiān)
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346 次 Piezo1 介導的星狀細胞活化導致小鼠壓力誘導的胰腺纖維化 2025-4-15
Piezo1-mediated stellate cell activation causes pressure-induced pancreatic fibrosis in miceKeywords: Fibrosis; Gastroenterology.慢性胰腺炎是一種胰腺組織進行性炎癥性疾病，其特征是產(chǎn)
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294 次 Piezo1 通道調(diào)控結(jié)膜上皮細胞 IL表達:機械應力與眼部炎癥關(guān)聯(lián)研究 2025-4-14
Mechanoreceptor Piezo1 channel-mediated interleukin expression in conjunctival epithelial cells: Linking mechanical stress to ocular inflammationKeywords: CREB; Conjunctival epithe
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253 次 糖苷內(nèi)切酶H從蛋白質(zhì)糖基化分析到蛋白質(zhì)折疊應用 2025-4-8
糖苷內(nèi)切酶H（Endoglycosidase H，Endo H）是一種特異性識別和切割N-連接寡糖的內(nèi)切糖苷酶。它在糖生物學、蛋白質(zhì)組學、生物制藥等領(lǐng)域具有廣泛的研究和應用價值。下面我將詳細介紹Endo H的研究
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372 次 骨肉瘤與巨噬細胞相互作用的IL-8經(jīng) FAK 促進瘤生長轉(zhuǎn)移 2025-4-8
Pivotal role of IL-8 derived from the interaction between osteosarcoma and tumor-associated macrophages in osteosarcoma growth and metastasis via the FAK pathwaySubject terms: Bone
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388 次 NETosis 驅(qū)動高血壓患者血壓升高和血管功能障礙 2025-4-7
NETosis Drives Blood Pressure Elevation and Vascular Dysfunction in HypertensionKeywords: extracellular traps; histones; hypertension; neutrophils; protein-arginine deiminase type
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324 次 微生理系統(tǒng)產(chǎn)生的剪切力可減少關(guān)節(jié)炎3D模型中TNF-α介導的軟骨損傷 2025-4-1
Microphysiological System-Generated Physiological Shear Forces Reduce TNF-α-Mediated Cartilage Damage in a 3D Model of ArthritisKeywords: TNF‐α; articular cartilage br
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369 次 牙髓干細胞調(diào)節(jié)真皮成纖維細胞的炎癥小體通路和膠原沉積 2025-3-31
Dental Pulp Stem Cells Modulate Inflammasome Pathway and Collagen Deposition of Dermal FibroblastsKeywords: dental pulp stem cells; fibroblasts; fibrosis; inflammasome; inflammatio
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196 次 Tenascin-X 介導血流誘導的 EndMT 和動脈粥樣硬化抑制 2025-3-25
Tenascin-X Mediates Flow-Induced Suppression of EndMT and AtherosclerosisKeywords: atherosclerosis; carotid arteries; endothelium; hemodynamics; inflammation; transforming growth f
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284 次 芥菜籽過敏原 Sina1 激活腸上皮細胞與樹突狀細胞 2025-3-24
Mustard seed major allergen Sin a1 activates intestinal epithelial cells and also dendritic cells that drive type 2 immune responsesKWS：Mustard seed；Sin a1；intestinal epithelial
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176 次 動脈粥樣硬化和內(nèi)皮機械轉(zhuǎn)導 2025-3-17
Atherosclerosis and endothelial mechanotransduction: current knowledge and models for future researchKeywords: atherosclerosis; endothelial cell glycocalyx; mechanotransduction; sh
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333 次 HEG1 通過調(diào)節(jié)內(nèi)皮細胞中KLF2/4 表達來預防動脈粥樣硬化 2025-3-17
HEG1 Protects Against Atherosclerosis by Regulating Stable Flow-Induced KLF2/4 Expression in Endothelial CellsKeywords: KLF2/4; atherosclerosis; endothelial cells; heart-of-glass 1
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